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Characterization of HIV-1 CRF01_AE env Genes Derived from Recently Infected Indonesian Individuals.


ABSTRACT: To eradicate human immunodeficiency virus type 1 (HIV-1) infection, a comprehensive strategy including preventive vaccine development is needed. Envelope glycoproteins (Env) play a central role in viral infection and are the major targets of humoral immune responses. Therefore, Env is a candidate vaccine antigen, and its characterization is necessary for vaccine development. The characterization of the transmitted/founder (T/F; i.e., recently infected) virus that is responsible for the establishment of infection and induction of primary anti-HIV-1 immune responses is important. We herein established HIV-1 env clones derived from recently infected Indonesian individuals. All env genes were classified into CRF01_AE. The immunological characterization of env clones was performed by neutralization tests using a series of broadly neutralizing antibodies. The present study is the first to immunologically characterize the CRF01_AE T/F virus circulating in Indonesia.

SUBMITTER: Sasaki M 

PROVIDER: S-EPMC7071041 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Characterization of HIV-1 CRF01_AE <i>env</i> Genes Derived from Recently Infected Indonesian Individuals.

Sasaki Maho M   Kotaki Tomohiro T   Khairunisa Siti Qamariyah SQ   Tachibana Shingo S   Ophinni Youdiil Y   Hayashi Yoshitake Y   Nasronudin   Kameoka Masanori M  

AIDS research and human retroviruses 20191003 3


To eradicate human immunodeficiency virus type 1 (HIV-1) infection, a comprehensive strategy including preventive vaccine development is needed. Envelope glycoproteins (Env) play a central role in viral infection and are the major targets of humoral immune responses. Therefore, Env is a candidate vaccine antigen, and its characterization is necessary for vaccine development. The characterization of the transmitted/founder (T/F; i.e., recently infected) virus that is responsible for the establish  ...[more]

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2020-05-15 | GSE126230 | GEO