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Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study.

ABSTRACT: Whether the affinity of serum vitamin E with total lipids hampers the appropriate assessment of its association with age-related risk factors has not been investigated in epidemiological studies. We aimed to compare linear regression-derived coefficients of the association of non-indexed and total lipids-indexed vitamin E isoforms with clinical and laboratory characteristics pertaining to the lipid, metabolic syndrome, and one-carbon metabolism biological domains. We studied 1429 elderly subjects (non-vitamin supplement users, 60-75 years old, with low and high socioeconomic status) from the population-based LifeLines Cohort and Biobank Study. We found that the associations of tocopherol isoforms with lipids were inverted in total lipids-indexed analyses, which may be indicative of overcorrection. Irrespective of the methods of standardization, we consistently found positive associations of ?-tocopherol with vitamins of the one-carbon metabolism pathway and inverse associations with characteristics related to glucose metabolism. The associations of ?-tocopherol were often opposite to those of ?-tocopherol. These data suggest that tocopherol isoforms and one-carbon metabolism are related, with beneficial and adverse associations for ?-tocopherol and ?-tocopherol, respectively. Whether tocopherol isoforms, or their interplay, truly affect the one-carbon metabolism pathway remains to be further studied.

SUBMITTER: Sotomayor CG

PROVIDER: S-EPMC7071362 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study.

Sotomayor Camilo G CG Minović Isidor I Eggersdorfer Manfred L ML Riphagen Ineke J IJ de Borst Martin H MH Dekker Louise H LH Nolte Ilja M IM Frank Jan J van Zon Sander K R SKR Reijneveld Sijmen A SA van der Molen Jan C JC Vos Michel J MJ Kootstra-Ros Jenny E JE Rodrigo Ramón R Kema Ido P IP Navis Gerjan J GJ Bakker Stephan J L SJL

Nutrients 20200223 2

Whether the affinity of serum vitamin E with total lipids hampers the appropriate assessment of its association with age-related risk factors has not been investigated in epidemiological studies. We aimed to compare linear regression-derived coefficients of the association of non-indexed and total lipids-indexed vitamin E isoforms with clinical and laboratory characteristics pertaining to the lipid, metabolic syndrome, and one-carbon metabolism biological domains. We studied 1429 elderly subject ...[more]

PMID: 32102191

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Project description:Clinical studies of the associations of vitamin E with lung function have reported conflicting results. However, these reports primarily examine the ?-tocopherol isoform of vitamin E and have not included the isoform ?-tocopherol which we recently demonstrated in vitro opposes the function of ?-tocopherol. We previously demonstrated, in vitro and in animal studies, that the vitamin E isoform ?-tocopherol protects, but the isoform ?-tocopherol promotes lung inflammation and airway hyperresponsiveness.To translate these findings to humans, we conducted analysis of 4526 adults in the Coronary Artery Risk Development in Young Adults (CARDIA) multi-center cohort with available spirometry and tocopherol data in blacks and whites. Spirometry was obtained at years 0, 5, 10, and 20 and serum tocopherol was from years 0, 7 and 15 of CARDIA.In cross-sectional regression analysis at year 0, higher ?-tocopherol associated with lower FEV1 (p = 0.03 in blacks and p = 0.01 in all participants) and FVC (p = 0.01 in blacks, p = 0.05 in whites, and p = 0.005 in all participants), whereas higher ?-tocopherol associated with higher FVC (p = 0.04 in blacks and whites and p = 0.01 in all participants). In the lowest quartile of ?-tocopherol, higher ?-tocopherol associated with a lower FEV1 (p = 0.05 in blacks and p = 0.02 in all participants). In contrast, in the lowest quartile of ?-tocopherol, higher ?-tocopherol associated with a higher FEV1 (p = 0.03) in blacks. Serum ?-tocopherol >10 ?M was associated with a 175-545 ml lower FEV1 and FVC at ages 21-55 years.Increasing serum concentrations of ?-tocopherol were associated with lower FEV1 or FVC, whereas increasing serum concentrations of ?-tocopherol was associated with higher FEV1 or FVC. Based on the prevalence of serum ?-tocopherol >10 ?M in adults in CARDIA and the adult U.S. population in the 2011 census, we expect that the lower FEV1 and FVC at these concentrations of serum ?-tocopherol occur in up to 4.5 million adults in the population.

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Dataset Information

Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study.

Publications

Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study.

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