Ontology highlight
ABSTRACT:
SUBMITTER: Bokas A
PROVIDER: S-EPMC7072375 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Bokas Alexandros A Papakotoulas Pavlos P Sarantis Panagiotis P Papadimitropoulou Adriana A Papavassiliou Athanasios G AG Karamouzis Michalis V MV
Cancers 20200213 2
Immune checkpoint inhibitors have revolutionized cancer treatment in the last decade. Despite the progress in immunotherapy, most pancreatic cancer patients still do not derive benefit when receiving immune-based therapies. Recently, resistance mechanisms to immune therapies have been mainly focused on tumor microenvironment properties. Pancreatic cancer is considered one of the most lethal and difficult to treat tumors due to its highly immunosuppressive and desmoplastic microenvironment. Low m ...[more]