Ontology highlight
ABSTRACT:
SUBMITTER: Butt E
PROVIDER: S-EPMC7072741 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Butt Elke E Stempfle Katrin K Lister Lorenz L Wolf Felix F Kraft Marcella M Herrmann Andreas B AB Viciano Cristina Perpina CP Weber Christian C Hochhaus Andreas A Ernst Thomas T Hoffmann Carsten C Zernecke Alma A Frietsch Jochen J JJ
Cells 20200214 2
The serine/threonine protein kinase AKT1 is a downstream target of the chemokine receptor 4 (CXCR4), and both proteins play a central role in the modulation of diverse cellular processes, including proliferation and cell survival. While in chronic myeloid leukemia (CML) the CXCR4 is downregulated, thereby promoting the mobilization of progenitor cells into blood, the receptor is highly expressed in breast cancer cells, favoring the migratory capacity of these cells. Recently, the LIM and SH3 dom ...[more]