Ontology highlight
ABSTRACT:
SUBMITTER: Esteve Cols C
PROVIDER: S-EPMC7073027 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Esteve Cols Clara C Graterol Torres Freddzia-Amanda FA Quirant Sánchez Bibiana B Marco Rusiñol Helena H Navarro Díaz Maruja Isabel MI Ara Del Rey Jordi J Martínez Cáceres Eva Mª EM
International journal of molecular sciences 20200218 4
The current gold-standard diagnostic technique for IgA nephropathy (IgAN), the leading form of primary glomerulonephritis, is renal biopsy. CD89 (the main IgA receptor) is expressed on the surface of monocytes and plays a role in disease pathogenesis. Immunocomplexes formed by sCD89 (soluble form) and Gd-IgA1 are related to disease prognosis. We hypothesize that reduced CD89 surface expression on monocytes may be a marker of disease severity. We aimed to analyze leukocyte subpopulations in perip ...[more]