Ontology highlight
ABSTRACT:
SUBMITTER: Nagai N
PROVIDER: S-EPMC7076486 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Nagai Noriaki N Ishii Miyu M Seiriki Ryotaro R Ogata Fumihiko F Otake Hiroko H Nakazawa Yosuke Y Okamoto Norio N Kanai Kazutaka K Kawasaki Naohito N
Pharmaceutics 20200214 2
The commercially available rebamipide ophthalmic suspension (CA-REB) was approved for clinical use in patients with dry eye; however, the residence time on the ocular surface for the traditional formulations is short, since the drug is removed from the ocular surface through the nasolacrimal duct. In this study, we designed a novel sustained-release drug delivery system (DDS) for dry eye therapy by rebamipide nanoparticles. The rebamipide solid nanoparticle-based ophthalmic formulation (REB-NPs) ...[more]