Ontology highlight
ABSTRACT:
SUBMITTER: Pedersen H
PROVIDER: S-EPMC7084771 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Pedersen Henriette H Anne Adanma Obara Elisabeth E Elbæk Kirstine Juul KJ Vitting-Serup Kristoffer K Hamerlik Petra P
International journal of molecular sciences 20200226 5
Glioblastoma (GBM) is among the deadliest of solid tumors with median survival rates of approximately 12-15 months despite maximal therapeutic intervention. A rare population of self-renewing cells referred to as GBM cancer stem-like cells (GSCs) are believed to be the source of inevitable recurrence in GBM. GSCs exhibit preferential activation of the DNA damage response pathway (DDR) and evade ionizing radiation (IR) therapy by superior execution of DNA repair compared to their differentiated c ...[more]