Ontology highlight
ABSTRACT:
SUBMITTER: Honarpisheh P
PROVIDER: S-EPMC7084806 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Honarpisheh Pedram P Reynolds Caroline R CR Blasco Conesa Maria P MP Moruno Manchon Jose F JF Putluri Nagireddy N Bhattacharjee Meenakshi B MB Urayama Akihiko A McCullough Louise D LD Ganesh Bhanu P BP
International journal of molecular sciences 20200303 5
Amyloid plaques in Alzheimer's disease (AD) are associated with inflammation. Recent studies demonstrated the involvement of the gut in cerebral amyloid-beta (Aβ) pathogenesis; however, the mechanisms are still not well understood. We hypothesize that the gut bears the Aβ burden prior to brain, highlighting gut-brain axis (GBA) interaction in neurodegenerative disorders. We used pre-symptomatic (6-months) and symptomatic (15-months) Tg2576 mouse model of AD compared to their age-matched litterma ...[more]