Ontology highlight
ABSTRACT:
SUBMITTER: Nagarajan P
PROVIDER: S-EPMC7093178 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Aging 20200313 5
Protein N-ε-lysine acetylation is is an important post-translational modification that plays critical roles in the regulation of many cellular processes. A role for this modification in the process of aging goes back two decades to the discovery that the yeast NAD<sup>+</sup>-dependent histone deacetylase Sir2 regulates lifespan in yeast. While the Sirtuin family of protein deacetylases has been intensively studied in many model systems and is definitively linked to aging, the enzymes responsibl ...[more]