Dataset Information

Management and outcomes of acute respiratory distress syndrome patients with and without comorbid conditions.

ABSTRACT:

Rationale

The standard of care for patients with acute respiratory distress syndrome (ARDS) has been developed based on studies that usually excluded patients with major comorbidities.

Objectives

To describe treatments and outcomes according to comorbidities in patients with ARDS admitted to 19 ICUs (1997-2014).

Methods

Patients were grouped based on comorbidities. Determinants of day-28 mortality were identified by multivariable Cox analysis stratified on center.

Measurements and main results

Among 4953 ARDS patients, 2545 (51.4%) had major comorbidities; the proportion with major comorbidities increased after 2008. Hematological malignancy was associated with severe ARDS and rescue therapies for refractory hypoxemia. COPD, HIV infection, and hematological malignancy were associated with a lower likelihood of invasive mechanical ventilation on the admission day. Admission-day SOFA score was higher in patients with major comorbidities, who more often received vasopressors, dialysis, or treatment-limitation decisions. Day-28 mortality was 33.7% overall, 27.2% in patients without major comorbidities, and 31.1% (COPD) to 56% (hematological malignancy) in patients with major comorbidities. By multivariable analysis, mortality was lower in patients with COPD and higher in those with chronic heart failure, solid tumors, or hematological malignancies. Mortality was independently associated with P_aO₂/F_iO₂ and PaCO₂ on day 1, ARDS of pulmonary origin, worse SOFA score, and ICU-acquired events.

Conclusions

Half the patients with ARDS had major comorbidities, which were associated with severe ARDS, multiple organ dysfunction, and day-28 mortality. These findings do not support the exclusion of ARDS patients with severe comorbidities from randomized clinical trials. Trials in ARDS patients with whatever comorbidities are warranted.

SUBMITTER: Azoulay E

PROVIDER: S-EPMC7095161 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Publications

Management and outcomes of acute respiratory distress syndrome patients with and without comorbid conditions.

Azoulay Elie E Lemiale Virginie V Mourvillier Bruno B Garrouste-Orgeas Maite M Schwebel Carole C Ruckly Stéphane S Argaud Laurent L Cohen Yves Y Souweine Bertrand B Papazian Laurent L Reignier Jean J Marcotte Guillaume G Siami Shidasp S Kallel Hatem H Darmon Michael M Timsit Jean-François JF

Intensive care medicine 20180607 7

<h4>Rationale</h4>The standard of care for patients with acute respiratory distress syndrome (ARDS) has been developed based on studies that usually excluded patients with major comorbidities.<h4>Objectives</h4>To describe treatments and outcomes according to comorbidities in patients with ARDS admitted to 19 ICUs (1997-2014).<h4>Methods</h4>Patients were grouped based on comorbidities. Determinants of day-28 mortality were identified by multivariable Cox analysis stratified on center.<h4>Measur ...[more]

PMID: 29881987

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Project description:BackgroundIn studies prior to lung-protective ventilation, liver cirrhosis in acute respiratory distress syndrome (ARDS) was associated with high mortality rates. Since patients with cirrhosis have been excluded from many trials on ARDS, their outcome when treated with lung-protective ventilation is unclear. The objectives were to assess whether cirrhosis is associated with mortality in ARDS and trends over time in mortality and severity.MethodsWe conducted a retrospective analysis of a prospective observational cohort conducted in a 20-bed tertiary ICU from October 2003 to December 2021. All consecutive adult critically ill patients with ARDS were included. ARDS was defined by the Berlin criteria. The primary outcome was 90 day mortality, assessed with Kaplan-Meier curves and multivariate Cox analysis. Time trends were assessed on 90 day mortality, Sequential Organ-Function Assessment score (SOFA) and non-hepatic SOFA. Ventilation settings were compared between patients with and without cirrhosis.ResultsOf the 7155 patients screened, 863 had a diagnosis of ARDS. Among these ARDS patients, 157(18%) had cirrhosis. The overall 90 day mortality was of 43% (378/863), 57% (90/157) in patients with cirrhosis and 41% (288/706) in patients without cirrhosis (p < 0.001). On survival curves, cirrhosis was associated with 90 day mortality (p < 0.001). Cirrhosis was independently associated with 90 day mortality in multivariate analysis (hazard ratio = 1.56, 95% confidence interval 1.20-2.02). There was no change in mortality over time in ARDS patients with and without cirrhosis. SOFA (p = 0.04) and non-hepatic SOFA (p = 0.02) increased over time in ARDS patients without cirrhosis, and remained stable in ARDS patients with cirrhosis. Tidal volume, positive end-expiratory pressure, plateau pressure and driving pressure were not different between ARDS patients with and without cirrhosis.ConclusionsAlthough ARDS management improved over the last decades, the 90 day mortality remained high and stable over time for both ARDS patients with (57%) and without cirrhosis (41%). Nevertheless, the severity of patients without cirrhosis has increased over time, while the severity of patients with cirrhosis has remained stable.

Dataset Information

Management and outcomes of acute respiratory distress syndrome patients with and without comorbid conditions.

Rationale

Objectives

Methods

Measurements and main results

Conclusions

Publications

Management and outcomes of acute respiratory distress syndrome patients with and without comorbid conditions.

Similar Datasets

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