Ontology highlight
ABSTRACT:
SUBMITTER: Bernier LP
PROVIDER: S-EPMC7096448 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Nature communications 20200325 1
Microglia are highly motile cells that continuously monitor the brain environment and respond to damage-associated cues. While glucose is the main energy substrate used by neurons in the brain, the nutrients metabolized by microglia to support surveillance of the parenchyma remain unexplored. Here, we use fluorescence lifetime imaging of intracellular NAD(P)H and time-lapse two-photon imaging of microglial dynamics in vivo and in situ, to show unique aspects of the microglial metabolic signature ...[more]