Ontology highlight
ABSTRACT:
SUBMITTER: Mahadeo KM
PROVIDER: S-EPMC7096894 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Nature reviews. Clinical oncology 20190101 1
In 2017, an autologous chimeric antigen receptor (CAR) T cell therapy indicated for children and young adults with relapsed and/or refractory CD19<sup>+</sup> acute lymphoblastic leukaemia became the first gene therapy to be approved in the USA. This innovative form of cellular immunotherapy has been associated with remarkable response rates but is also associated with unique and often severe toxicities, which can lead to rapid cardiorespiratory and/or neurological deterioration. Multidisciplina ...[more]