Ontology highlight
ABSTRACT:
SUBMITTER: Zhai Y
PROVIDER: S-EPMC7096913 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20051101 11
Coronavirus replication and transcription machinery involves multiple virus-encoded nonstructural proteins (nsp). We report the crystal structure of the hexadecameric nsp7-nsp8 supercomplex from the severe acute respiratory syndrome coronavirus at 2.4-angstroms resolution. nsp8 has a novel 'golf-club' fold with two conformations. The supercomplex is a unique hollow, cylinder-like structure assembled from eight copies of nsp8 and held tightly together by eight copies of nsp7. With an internal dia ...[more]