Ontology highlight
ABSTRACT:
SUBMITTER: Peng Q
PROVIDER: S-EPMC7260489 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Cell reports 20200530 11
The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has caused a huge number of human deaths. Currently, there are no specific drugs or vaccines available for this virus (SARS-CoV-2). The viral polymerase is a promising antiviral target. Here, we describe the near-atomic-resolution structure of the SARS-CoV-2 polymerase complex consisting of the nsp12 catalytic subunit and nsp7-nsp8 cofactors. This structure highly resembles the counterpart of SARS-CoV with conserved motifs for al ...[more]