Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh E
PROVIDER: S-EPMC7099875 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Ghosh Eshan E Dwivedi Hemlata H Baidya Mithu M Srivastava Ashish A Kumari Punita P Stepniewski Tomek T Kim Hee Ryung HR Lee Mi-Hye MH van Gastel Jaana J Chaturvedi Madhu M Roy Debarati D Pandey Shubhi S Maharana Jagannath J Guixà-González Ramon R Luttrell Louis M LM Chung Ka Young KY Dutta Somnath S Selent Jana J Shukla Arun K AK
Cell reports 20190901 13
Desensitization, signaling, and trafficking of G-protein-coupled receptors (GPCRs) are critically regulated by multifunctional adaptor proteins, β-arrestins (βarrs). The two isoforms of βarrs (βarr1 and 2) share a high degree of sequence and structural similarity; still, however, they often mediate distinct functional outcomes in the context of GPCR signaling and regulation. A mechanistic basis for such a functional divergence of βarr isoforms is still lacking. By using a set of complementary ap ...[more]