Ontology highlight
ABSTRACT:
SUBMITTER: Jalily PH
PROVIDER: S-EPMC7102647 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Jalily Pouria H PH Duncan Maggie C MC Fedida David D Wang Jun J Tietjen Ian I
Antiviral research 20200327
The ongoing threat of seasonal and pandemic influenza to human health requires antivirals that can effectively supplement existing vaccination strategies. The M2 protein of influenza A virus (IAV) is a proton-gated, proton-selective ion channel that is required for virus replication and is an established antiviral target. While licensed adamantane-based M2 antivirals have been historically used, M2 mutations that confer major adamantane resistance are now so prevalent in circulating virus strain ...[more]