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Put a cork in it: Plugging the M2 viral ion channel to sink influenza.


ABSTRACT: The ongoing threat of seasonal and pandemic influenza to human health requires antivirals that can effectively supplement existing vaccination strategies. The M2 protein of influenza A virus (IAV) is a proton-gated, proton-selective ion channel that is required for virus replication and is an established antiviral target. While licensed adamantane-based M2 antivirals have been historically used, M2 mutations that confer major adamantane resistance are now so prevalent in circulating virus strains that these drugs are no longer recommended. Here we review the current understanding of IAV M2 structure and function, mechanisms of inhibition, the rise of drug resistance mutations, and ongoing efforts to develop new antivirals that target resistant forms of M2.

SUBMITTER: Jalily PH 

PROVIDER: S-EPMC7102647 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Put a cork in it: Plugging the M2 viral ion channel to sink influenza.

Jalily Pouria H PH   Duncan Maggie C MC   Fedida David D   Wang Jun J   Tietjen Ian I  

Antiviral research 20200327


The ongoing threat of seasonal and pandemic influenza to human health requires antivirals that can effectively supplement existing vaccination strategies. The M2 protein of influenza A virus (IAV) is a proton-gated, proton-selective ion channel that is required for virus replication and is an established antiviral target. While licensed adamantane-based M2 antivirals have been historically used, M2 mutations that confer major adamantane resistance are now so prevalent in circulating virus strain  ...[more]

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