Ontology highlight
ABSTRACT:
SUBMITTER: He M
PROVIDER: S-EPMC7104778 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Cell metabolism 20200206 3
It is well documented that the rate of aging can be slowed, but it remains unclear to which extent aging-associated conditions can be reversed. How the interface of immunity and metabolism impinges upon the diabetes pandemic is largely unknown. Here, we show that NLRP3, a pattern recognition receptor, is modified by acetylation in macrophages and is deacetylated by SIRT2, an NAD<sup>+</sup>-dependent deacetylase and a metabolic sensor. We have developed a cell-based system that models aging-asso ...[more]