Ontology highlight
ABSTRACT:
SUBMITTER: Chang YW
PROVIDER: S-EPMC7933514 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Chang Yu-Wei YW Hung Ling-Chien LC Chen Yu-Cheng YC Wang Wen-Hung WH Lin Chun-Yu CY Tzeng Hsin-Han HH Suen Jau-Ling JL Chen Yen-Hsu YH
Frontiers in immunology 20210219
The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is the platform for IL-1β maturation, aimed at mediating a rapid immune response against danger signals which must be tightly regulated. Insulin is well known as the critical hormone in the maintenance of glucose in physiologic response. Previous studies have proved insulin has the anti-inflammatory effect but the molecular mechanism of immunomodulation provided by insulin is not clear so far. Here we investigated whether ...[more]