Ontology highlight
ABSTRACT:
SUBMITTER: Bawa S
PROVIDER: S-EPMC7105379 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
eLife 20200330
Cell growth and/or proliferation may require the reprogramming of metabolic pathways, whereby a switch from oxidative to glycolytic metabolism diverts glycolytic intermediates towards anabolic pathways. Herein, we identify a novel role for TRIM32 in the maintenance of glycolytic flux mediated by biochemical interactions with the glycolytic enzymes Aldolase and Phosphoglycerate mutase. Loss of <i>Drosophila</i> TRIM32, encoded by <i>thin (tn)</i>, shows reduced levels of glycolytic intermediates ...[more]