Ontology highlight
ABSTRACT:
SUBMITTER: Zhao S
PROVIDER: S-EPMC7109629 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Zhao Shuangshuang S Shi Xuemeng X Zhang Yue Y Wen Zeyu Z Cai Jinping J Gao Wei W Xu Jiayi J Zheng Yifei Y Ji Baohua B Cui Yanqin Y Shi Kun K Liu Yanjun Y Li Hui H Jiu Yaming Y
iScience 20200311 4
Actin stress fibers guide cell migration and morphogenesis. During centripetal flow, actin transverse arcs fuse accompanied by the formation of myosin II stacks to generate mechanosensitive actomyosin bundles. However, whether myosin II stack formation plays a role in cell mechano-sensing has remained elusive. Myosin-18B is a "glue" molecule for assembling myosin II stacks. By examining actin networks and traction forces, we find that cells abolishing myosin-18B resemble Ca<sup>2+</sup>∕calmodul ...[more]