The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice.
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ABSTRACT:
SUBMITTER: Ritschka B
PROVIDER: S-EPMC7111259 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
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The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice.
Ritschka Birgit B Knauer-Meyer Tania T Gonçalves Daniel Sampaio DS Mas Alba A Plassat Jean-Luc JL Durik Matej M Jacobs Hugues H Pedone Elisa E Di Vicino Umberto U Cosma Maria Pia MP Keyes William M WM
Genes & development 20200305 7-8
Young mammals possess a limited regenerative capacity in some tissues, which is lost upon maturation. We investigated whether cellular senescence might play a role in such loss during liver regeneration. We found that following partial hepatectomy, the senescence-associated genes p21, p16<sup>Ink4a</sup>, and p19<sup>Arf</sup> become dynamically expressed in different cell types when regenerative capacity decreases, but without a full senescent response. However, we show that treatment with a se ...[more]
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