Ontology highlight
ABSTRACT:
SUBMITTER: Dong W
PROVIDER: S-EPMC7114126 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Dong Wanyu W Xie Wenting W Liu Yunbo Y Sui Baokun B Zhang Hao H Liu Liran L Tan Yubei Y Tong Xiaohan X Fu Zhen F ZF Yin Ping P Fang Liurong L Peng Guiqing G
Antiviral research 20191118
Emerging coronaviruses (CoVs) primarily cause severe gastroenteric or respiratory diseases in humans and animals, and no approved therapeutics are currently available. Here, A9, a receptor tyrosine kinase inhibitor (RTKI) of the tyrphostin class, is identified as a robust inhibitor of transmissible gastroenteritis virus (TGEV) infection in cell-based assays. Moreover, A9 exhibited potent antiviral activity against the replication of various CoVs, including murine hepatitis virus (MHV), porcine e ...[more]