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Regulation of cellular senescence by eukaryotic members of the FAH superfamily - A role in calcium homeostasis?


ABSTRACT: Fumarylacetoacetate hydrolase (FAH) superfamily members are commonly expressed in the prokaryotic kingdom, where they take part in the committing steps of degradation pathways of complex carbon sources. Besides FAH itself, the only described FAH superfamily members in the eukaryotic kingdom are fumarylacetoacetate hydrolase domain containing proteins (FAHD) 1 and 2, that have been a focus of recent work in aging research. Here, we provide a review of current knowledge on FAHD proteins. Of those, FAHD1 has recently been described as a regulator of mitochondrial function and senescence, in the context of mitochondrial dysfunction associated senescence (MiDAS). This work further describes data based on bioinformatics analysis, 3D structure comparison and sequence alignment, that suggests a putative role of FAHD proteins as calcium binding proteins.

SUBMITTER: Weiss AKH 

PROVIDER: S-EPMC7116474 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Regulation of cellular senescence by eukaryotic members of the FAH superfamily - A role in calcium homeostasis?

Weiss Alexander K H AKH   Albertini Eva E   Holzknecht Max M   Cappuccio Elia E   Dorigatti Ilaria I   Krahbichler Anna A   Damisch Elisabeth E   Gstach Hubert H   Jansen-Dürr Pidder P  

Mechanisms of ageing and development 20200620


Fumarylacetoacetate hydrolase (FAH) superfamily members are commonly expressed in the prokaryotic kingdom, where they take part in the committing steps of degradation pathways of complex carbon sources. Besides FAH itself, the only described FAH superfamily members in the eukaryotic kingdom are fumarylacetoacetate hydrolase domain containing proteins (FAHD) 1 and 2, that have been a focus of recent work in aging research. Here, we provide a review of current knowledge on FAHD proteins. Of those,  ...[more]