Ontology highlight
ABSTRACT:
SUBMITTER: Moran SJ
PROVIDER: S-EPMC7119126 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Moran Stephen J SJ Flanagan John F JF Namy Olivier O Stuart David I DI Brierley Ian I Gilbert Robert J C RJ
Structure (London, England : 1993) 20080501 5
The translation of genetic information into proteins is a fundamental process of life. Stepwise addition of amino acids to the growing polypeptide chain requires the coordinated movement of mRNA and tRNAs through the ribosome, a process known as translocation. Here, we review current understanding of the kinetics and mechanics of translocation, with particular emphasis on the structure of a functional mammalian ribosome stalled during translocation by an mRNA pseudoknot. In the context of a pseu ...[more]