Ontology highlight
ABSTRACT:
SUBMITTER: Casanova-Acebes M
PROVIDER: S-EPMC7125161 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Nature communications 20200403 1
Tissue-resident macrophages (TRMs) populate all tissues and play key roles in homeostasis, immunity and repair. TRMs express a molecular program that is mostly shaped by tissue cues. However, TRM identity and the mechanisms that maintain TRMs in tissues remain poorly understood. We recently found that serous-cavity TRMs (LPMs) are highly enriched in RXR transcripts and RXR-response elements. Here, we show that RXRs control mouse serous-macrophage identity by regulating chromatin accessibility an ...[more]