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The receptor binding domain of MERS-CoV: the dawn of vaccine and treatment development.

ABSTRACT: The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) is becoming another "SARS-like" threat to the world. It has an extremely high death rate (?50%) as there is no vaccine or efficient therapeutics. The identification of the structures of both the MERS-CoV receptor binding domain (RBD) and its complex with dipeptidyl peptidase 4 (DPP4), raises the hope of alleviating this currently severe situation. In this review, we examined the molecular basis of the RBD-receptor interaction to outline why/how could we use MERS-CoV RBD to develop vaccines and antiviral drugs.

SUBMITTER: Zhou N

PROVIDER: S-EPMC7127315 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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The receptor binding domain of MERS-CoV: the dawn of vaccine and treatment development.

Zhou Nan N Zhang Yun Y Zhang Jin-Chun JC Feng Ling L Bao Jin-Ku JK

Journal of the Formosan Medical Association = Taiwan yi zhi 20131215 3

The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) is becoming another "SARS-like" threat to the world. It has an extremely high death rate (∼50%) as there is no vaccine or efficient therapeutics. The identification of the structures of both the MERS-CoV receptor binding domain (RBD) and its complex with dipeptidyl peptidase 4 (DPP4), raises the hope of alleviating this currently severe situation. In this review, we examined the molecular basis of the RBD-receptor interact ...[more]

PMID: 24342026

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