Dataset Information

Vascular Positron Emission Tomography and Restenosis in Symptomatic Peripheral Arterial Disease: A Prospective Clinical Study.

ABSTRACT:

Objectives

This study determined whether in vivo positron emission tomography (PET) of arterial inflammation (¹⁸F-fluorodeoxyglucose [¹⁸F-FDG]) or microcalcification (¹⁸F-sodium fluoride [¹⁸F-NaF]) could predict restenosis following PTA.

Background

Restenosis following lower limb percutaneous transluminal angioplasty (PTA) is common, unpredictable, and challenging to treat. Currently, it is impossible to predict which patient will suffer from restenosis following angioplasty.

Methods

In this prospective observational cohort study, 50 patients with symptomatic peripheral arterial disease underwent ¹⁸F-FDG and ¹⁸F-NaF PET/computed tomography (CT) imaging of the superficial femoral artery before and 6 weeks after angioplasty. The primary outcome was arterial restenosis at 12 months.

Results

Forty subjects completed the study protocol with 14 patients (35%) reaching the primary outcome of restenosis. The baseline activities of femoral arterial inflammation (¹⁸F-FDG tissue-to-background ratio [TBR] 2.43 [interquartile range (IQR): 2.29 to 2.61] vs. 1.63 [IQR: 1.52 to 1.78]; p < 0.001) and microcalcification (¹⁸F-NaF TBR 2.61 [IQR: 2.50 to 2.77] vs. 1.69 [IQR: 1.54 to 1.77]; p < 0.001) were higher in patients who developed restenosis. The predictive value of both ¹⁸F-FDG (cut-off TBR_max value of 1.98) and ¹⁸F-NaF (cut-off TBR_max value of 2.11) uptake demonstrated excellent discrimination in predicting 1-year restenosis (Kaplan Meier estimator, log-rank p < 0.001).

Conclusions

Baseline and persistent femoral arterial inflammation and micro-calcification are associated with restenosis following lower limb PTA. For the first time, we describe a method of identifying complex metabolically active plaques and patients at risk of restenosis that has the potential to select patients for intervention and to serve as a biomarker to test novel interventions to prevent restenosis.

SUBMITTER: Chowdhury MM

PROVIDER: S-EPMC7136751 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Publications

Vascular Positron Emission Tomography and Restenosis in Symptomatic Peripheral Arterial Disease: A Prospective Clinical Study.

Chowdhury Mohammed M MM Tarkin Jason M JM Albaghdadi Mazen S MS Evans Nicholas R NR Le Elizabeth P V EPV Berrett Thomas B TB Sadat Umar U Joshi Francis R FR Warburton Elizabeth A EA Buscombe John R JR Hayes Paul D PD Dweck Marc R MR Newby David E DE Rudd James H F JHF Coughlin Patrick A PA

JACC. Cardiovascular imaging 20190612 4

<h4>Objectives</h4>This study determined whether in vivo positron emission tomography (PET) of arterial inflammation (<sup>18</sup>F-fluorodeoxyglucose [<sup>18</sup>F-FDG]) or microcalcification (<sup>18</sup>F-sodium fluoride [<sup>18</sup>F-NaF]) could predict restenosis following PTA.<h4>Background</h4>Restenosis following lower limb percutaneous transluminal angioplasty (PTA) is common, unpredictable, and challenging to treat. Currently, it is impossible to predict which patient will suffer ...[more]

PMID: 31202739

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Dataset Information

Vascular Positron Emission Tomography and Restenosis in Symptomatic Peripheral Arterial Disease: A Prospective Clinical Study.

Objectives

Background

Methods

Results

Conclusions

Publications

Vascular Positron Emission Tomography and Restenosis in Symptomatic Peripheral Arterial Disease: A Prospective Clinical Study.

Similar Datasets

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