Ontology highlight
ABSTRACT:
SUBMITTER: Nappi A
PROVIDER: S-EPMC7140064 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Nappi Annarita A Di Cicco Emery E Miro Caterina C Cicatiello Annunziata Gaetana AG Sagliocchi Serena S Mancino Giuseppina G Ambrosio Raffaele R Luongo Cristina C Di Girolamo Daniela D De Stefano Maria Angela MA Porcelli Tommaso T Stornaiuolo Mariano M Dentice Monica M
Cancers 20200318 3
Type 2 deiodinase (D2), the principal activator of thyroid hormone (TH) signaling in target tissues, is expressed in cutaneous squamous cell carcinomas (SCCs) during late tumorigenesis, and its repression attenuates the invasiveness and metastatic spread of SCC. Although D2 plays multiple roles in cancer progression, nothing is known about the mechanisms regulating D2 in cancer. To address this issue, we investigated putative upstream regulators of D2 in keratinocyte carcinomas. We found that th ...[more]