Deterioration of cognitive function after transient cerebral ischemia with amyloid-β infusion-possible amelioration of cognitive function by AT₂ receptor activation.

ABSTRACT:

Background

To promote understanding of the pathogenesis of cognitive impairment or dementia, we explored the potential interaction between transient cerebral ischemia and amyloid-β (Aβ) infusion in mediating cognitive decline and examined the possible ameliorative effect of angiotensin II type 2 (AT₂) receptor activation in vascular smooth muscle cells (VSMC) on this cognitive deficit.

Methods

Adult male wild-type mice (WT) and mice with VSMC-specific AT₂ receptor overexpression (smAT₂) were subjected to intracerebroventricular (ICV) injection of Aβ1-40. Transient cerebral ischemia was induced by 15 min of bilateral common carotid artery occlusion (BCCAO) 24 h after Aβ injection.

Results

Aβ injection in WT induced a cognitive decline,

SUBMITTER: Min LJ 

PROVIDER: S-EPMC7140348 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature