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Crosstalk between Dendritic Cells and Immune Modulatory Agents against Sepsis.

ABSTRACT: Dendritic cells (DCs) play a critical role in the immune system which sense pathogens and present their antigens to prime the adaptive immune responses. As the progression of sepsis occurs, DCs are capable of orchestrating the aberrant innate immune response by sustaining the Th1/Th2 responses that are essential for host survival. Hence, an in-depth understanding of the characteristics of DCs would have a beneficial effect in overcoming the obstacle occurring in sepsis. This paper focuses on the role of DCs in the progression of sepsis and we also discuss the reverse sepsis-induced immunosuppression through manipulating the DC function. In addition, we highlight some potent immunotherapies that could be used as a novel strategy in the early treatment of sepsis.

SUBMITTER: Wang G

PROVIDER: S-EPMC7140865 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Crosstalk between Dendritic Cells and Immune Modulatory Agents against Sepsis.

Wang Guoying G Li Xianghui X Zhang Lei L Elgaili Abdalla Abualgasim A Teng Tieshan T Li Yanzhang Y

Genes 20200318 3

Dendritic cells (DCs) play a critical role in the immune system which sense pathogens and present their antigens to prime the adaptive immune responses. As the progression of sepsis occurs, DCs are capable of orchestrating the aberrant innate immune response by sustaining the Th1/Th2 responses that are essential for host survival. Hence, an in-depth understanding of the characteristics of DCs would have a beneficial effect in overcoming the obstacle occurring in sepsis. This paper focuses on the ...[more]

PMID: 32197507

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