Ontology highlight
ABSTRACT:
SUBMITTER: Wang P
PROVIDER: S-EPMC7141973 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20200225 16
With the infection rate of Bordetella pertussis at a 60-year high, there is an urgent need for new anti-pertussis vaccines. The lipopolysaccharide (LPS) of B. pertussis is an attractive antigen for vaccine development. With the presence of multiple rare sugars and unusual glycosyl linkages, the B. pertussis LPS is a highly challenging synthetic target. In this work, aided by molecular dynamics simulation and modeling, a pertussis-LPS-like pentasaccharide was chemically synthesized for the first ...[more]