Ontology highlight
ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC7147094 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Li Shuangxi S Tian Aiguo A Li Shuang S Han Yuhong Y Wang Bing B Jiang Jin J
The Journal of cell biology 20200401 4
Adult tissues and organs rely on resident stem cells to generate new cells that replenish damaged cells. To maintain homeostasis, stem cell activity needs to be tightly controlled throughout the adult life. Here, we show that the membrane-associated kinase Gilgamesh (Gish)/CK1γ maintains Drosophila adult midgut homeostasis by restricting JNK pathway activity and that Gish is essential for intestinal stem cell (ISC) maintenance under stress conditions. Inactivation of Gish resulted in aberrant JN ...[more]