Ontology highlight
ABSTRACT:
SUBMITTER: Ervasti T
PROVIDER: S-EPMC7151305 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Ervasti Tuomas T Niinikoski Hannes H Mäki-Lohiluoma Eero E Leppinen Heidi H Ketolainen Jarkko J Korhonen Ossi O Lakio Satu S
Pharmaceutics 20200320 3
Segregation is a common problem in batch-based direct compression (BDC) processes, especially with low-dose tablet products, as is the preparation of a homogenous mixture. The scope of the current work was to explore if a continuous direct compression (CDC) process could serve as a solution for these challenges. Furthermore, the principle of a platform formulation was demonstrated for low dose tablets. The combination of filler excipients and the API in the formulation used was suitable for dire ...[more]