Identification of potential molecular targets associated with proliferative diabetic retinopathy.

ABSTRACT:

Background

This study aimed to identify and evaluate potential molecular targets associated with the development of proliferative diabetic retinopathy (DR).

Methods

The microarray dataset "GSE60436" generated from fibrovascular membranes (FVMs) associated with proliferative DR was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) from the active FVMs and control or inactive FVMs and control were evaluated and co-DEGs were identified using VEEN analysis. Functional enrichment analysis, and protein-protein interactions (PPI) network and module analyses were performed on the upregulated and downregulated coDEGs. Finally, several predictions regarding microRNAs (miRNAs) and transcription factors (TFs) were made to construct a putative TF

SUBMITTER: Shao D 

PROVIDER: S-EPMC7155274 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature