Ontology highlight
ABSTRACT:
SUBMITTER: Wiehagen KR
PROVIDER: S-EPMC3031404 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Wiehagen Karla R KR Corbo Evann E Schmidt Michelle M Shin Haina H Wherry E John EJ Maltzman Jonathan S JS
Blood 20100930 25
The requirements for tonic T-cell receptor (TCR) signaling in CD8(+) memory T-cell generation and homeostasis are poorly defined. The SRC homology 2 (SH2)-domain-containing leukocyte protein of 76 kDa (SLP-76) is critical for proximal TCR-generated signaling. We used temporally mediated deletion of SLP-76 to interrupt tonic and activating TCR signals after clearance of the lymphocytic choriomeningitis virus (LCMV). SLP-76-dependent signals are required during the contraction phase of the immune ...[more]