High plasma levels of pro-inflammatory factors interleukin-17 and interleukin-23 are associated with poor outcome of cardiac-arrest patients: a single center experience.

ABSTRACT: BACKGROUND:Systemic inflammation is an important feature of post-cardiac arrest syndrome (PCAS). This study was designed to determine whether the plasma concentrations of some circulating pro-inflammatory cytokines (interleukin-17 [IL-8], IL-22, IL-23 and IL-33) are of value in predicting the outcome of patients after return of spontaneous circulation (ROSC) during the post-cardiac arrest period. METHODS:This was a prospective observational clinical study. In total, 21 patients (survivors, n?=?10; non-survivors, n?=?11) who experienced cardiac arrest and successful ROSC with expected survival of at least 7?days were consecutively enrolled from January 2016 to December 2017. Of the 21 enrolled patients, ten survived were designated "survivors". The other eleven patients died between 2?days and 1?months post ROSC. Venous blood was drawn at three time-points: baseline (

SUBMITTER: Zhuang YG 

PROVIDER: S-EPMC7158084 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature