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Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals.

ABSTRACT: This article examines three aspects of antivirals, such as hydroxychloroquine, chloroquine, and remdesvir, as they might relate to the treatment of a viral infection such as COVID-19: (i) the use of vaporization for the delivery of antivirals, with the bulk constituents having mild antiviral efficacy; (ii) the application of a marine natural product extract as opposed to a single molecule as an antiviral agent; and (iii) a counter intuitive approach to formulation that is, in part, based on delivering multiple species that fall into three categories: building blocks for the virus to accelerate replication; an energy source for the infected cell to boost its immune response; and the species that antagonize or provide toxicity to the virus.

SUBMITTER: Manning TJ

PROVIDER: S-EPMC7169894 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals.

Manning Thomas J TJ Thomas-Richardson Jenu J Cowan Matthew M Beard Torien T

Drug discovery today 20200420 6

This article examines three aspects of antivirals, such as hydroxychloroquine, chloroquine, and remdesvir, as they might relate to the treatment of a viral infection such as COVID-19: (i) the use of vaporization for the delivery of antivirals, with the bulk constituents having mild antiviral efficacy; (ii) the application of a marine natural product extract as opposed to a single molecule as an antiviral agent; and (iii) a counter intuitive approach to formulation that is, in part, based on deli ...[more]

PMID: 32325124

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