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DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination.


ABSTRACT: Early dissemination is a unique characteristic and a detrimental process of pancreatic ductal adenocarcinoma (PDAC); however, the underlying mechanism remains largely unknown. Here, we investigate the role of dual-specificity phosphatase-2 (DUSP2)-vascular endothelial growth factor-C (VEGF-C) axis in mediating PDAC lymphangiogenesis and lymphovascular invasion. Expression of DUSP2 is greatly suppressed in PDAC, which results in increased aberrant expression of extracellular vesicle (EV)-associated VEGF-C secretion. EV-VEGF-C exerts paracrine effects on lymphatic endothelial cells and autocrine effects on cancer cells, resulting in the lymphovascular invasion of cancer cells. Tissue-specific knockout of Dusp2 in mouse pancreas recapitulates PDAC phenotype and lymphovascular invasion. Mechanistically, loss-of-DUSP2 enhances proprotein convertase activity and vesicle trafficking to promote the release of the mature form of EV-VEGF-C. Collectively, these findings represent a conceptual advance in understanding pancreatic cancer lymphovascular invasion and suggest that loss-of-DUSP2-mediated VEGF-C processing may play important roles in early dissemination of pancreatic cancer. Abbreviations: DUSP2: dual-specificity phosphatase-2; VEGF-C: vascular endothelial growth factor-C; EV: extracellular vesicles; PDAC: pancreatic ductal adenocarcinoma; KD: knockdown.

SUBMITTER: Wang CA 

PROVIDER: S-EPMC7170376 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination.

Wang Chu-An CA   Chang I-Heng IH   Hou Pei-Chi PC   Tai Yu-Jing YJ   Li Wan-Ning WN   Hsu Pei-Ling PL   Wu Shang-Rung SR   Chiu Wen-Tai WT   Li Chien-Feng CF   Shan Yan-Shen YS   Tsai Shaw-Jenq SJ  

Journal of extracellular vesicles 20200404 1


Early dissemination is a unique characteristic and a detrimental process of pancreatic ductal adenocarcinoma (PDAC); however, the underlying mechanism remains largely unknown. Here, we investigate the role of dual-specificity phosphatase-2 (DUSP2)-vascular endothelial growth factor-C (VEGF-C) axis in mediating PDAC lymphangiogenesis and lymphovascular invasion. Expression of DUSP2 is greatly suppressed in PDAC, which results in increased aberrant expression of extracellular vesicle (EV)-associat  ...[more]

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