Ontology highlight
ABSTRACT:
SUBMITTER: Avitabile M
PROVIDER: S-EPMC7171401 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Avitabile Marianna M Lasorsa Vito Alessandro VA Cantalupo Sueva S Cardinale Antonella A Cimmino Flora F Montella Annalaura A Capasso Dalila D Haupt Riccardo R Amoroso Loredana L Garaventa Alberto A Quattrone Alessandro A Corrias Maria Valeria MV Iolascon Achille A Capasso Mario M
Journal of cellular and molecular medicine 20200227 7
The genetic aetiology and the molecular mechanisms that characterize high-risk neuroblastoma are still little understood. The majority of high-risk neuroblastoma patients do not take advantage of current induction therapy. So far, one of the main reasons liable for cancer therapeutic failure is the acquisition of resistance to cytotoxic anticancer drugs, because of the DNA repair system of tumour cells. PARP1 is one of the main DNA damage sensors involved in the DNA repair system and genomic sta ...[more]