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Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia.


ABSTRACT: Early diagnosis of acute community-acquired pneumonia (CAP) is important in patient triage and treatment decisions. To identify biomarkers that distinguish patients with CAP from non-CAP controls, we conducted an untargeted global metabolome analysis for plasma samples from 142 patients with CAP (CAP cases) and 97 without CAP (non-CAP controls). Thirteen lipid metabolites could discriminate between CAP cases and non-CAP controls with area-under-the-receiver-operating-characteristic curve of >0.8 (P ? 10(-9)). The levels of glycosphingolipids, sphingomyelins, lysophosphatidylcholines and L-palmitoylcarnitine were higher, while the levels of lysophosphatidylethanolamines were lower in the CAP cases than those in non-CAP controls. All 13 metabolites could distinguish CAP cases from the non-infection, extrapulmonary infection and non-CAP respiratory tract infection subgroups. The levels of trihexosylceramide (d18:1/16:0) were higher, while the levels of lysophosphatidylethanolamines were lower, in the fatal than those of non-fatal CAP cases. Our findings suggest that lipid metabolites are potential diagnostic and prognostic biomarkers for CAP.

SUBMITTER: To KK 

PROVIDER: S-EPMC7173326 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia.

To Kelvin K W KK   Lee Kim-Chung KC   Wong Samson S Y SS   Sze Kong-Hung KH   Ke Yi-Hong YH   Lui Yin-Ming YM   Tang Bone S F BS   Li Iris W S IW   Lau Susanna K P SK   Hung Ivan F N IF   Law Chun-Yiu CY   Lam Ching-Wan CW   Yuen Kwok-Yung KY  

Diagnostic microbiology and infectious disease 20160314 2


Early diagnosis of acute community-acquired pneumonia (CAP) is important in patient triage and treatment decisions. To identify biomarkers that distinguish patients with CAP from non-CAP controls, we conducted an untargeted global metabolome analysis for plasma samples from 142 patients with CAP (CAP cases) and 97 without CAP (non-CAP controls). Thirteen lipid metabolites could discriminate between CAP cases and non-CAP controls with area-under-the-receiver-operating-characteristic curve of >0.8  ...[more]

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