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MetaboLights MTBLS354 - GNPS Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia

ABSTRACT: This data set is downloaded from MetaboLights (http://www.ebi.ac.uk/metabolights/) accession number MTBLS354 Abstract:Early diagnosis of acute community-acquired pneumonia (CAP) is important in patient triage and treatment decisions. To identify biomarkers that distinguish patients with CAP from non-CAP controls, we conducted an untargeted global metabolome analysis for plasma samples from142 patients with CAP (CAP cases) and 97 without CAP (non-CAP controls). Thirteen lipid metabolites could discriminate between CAP cases and non-CAP controls with area-under-the-receiver-operating-characteristic curve of > 8 (P ? 10-9). The levels of glycosphingolipids, sphingomyelins, lysophosphatidylcholines and L-palmitoylcarnitine were higher, while the levels of lysophosphatidylethanolamines were lower in the CAP cases than those in non-CAP controls. All 13 metabolites could distinguish CAP cases from the non-infection, extrapulmonary infection and non-CAP respiratory tract infection subgroups. The levels of trihexosylceramide (d18:1/16:0) were higher, while the levels of lysophosphatidylethanolamines were lower, in the fatal than those of non-fatal CAP cases. Our ?ndings suggest that lipid metabolites are potential diagnostic and prognostic biomarkers for CAP.

INSTRUMENT(S): 6540 Q-TOF LC/MS (Agilent)

ORGANISM(S): Homo Sapiens

SUBMITTER: Kwok-Yung

PROVIDER: MSV000080957 | GNPS | Sun Apr 16 12:25:00 BST 2017

REPOSITORIES: GNPS

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MetaboLights MTBLS354 - GNPS Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia

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