Dataset Information

Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia

ABSTRACT: Early diagnosis of acute community-acquired pneumonia (CAP) is important in patient triage and treatment decisions. To identify biomarkers that distinguish patients with CAP from non-CAP controls, we conducted an untargeted global metabolome analysis for plasma samples from142 patients with CAP (CAP cases) and 97 without CAP (non-CAP controls). Thirteen lipid metabolites could discriminate between CAP cases and non-CAP controls with area-under-the-receiver-operating-characteristic curve of > 8 (P ≤ 10-9). The levels of glycosphingolipids, sphingomyelins, lysophosphatidylcholines and L-palmitoylcarnitine were higher, while the levels of lysophosphatidylethanolamines were lower in the CAP cases than those in non-CAP controls. All 13 metabolites could distinguish CAP cases from the non-infection, extrapulmonary infection and non-CAP respiratory tract infection subgroups. The levels of trihexosylceramide (d18:1/16:0) were higher, while the levels of lysophosphatidylethanolamines were lower, in the fatal than those of non-fatal CAP cases. Our ﬁndings suggest that lipid metabolites are potential diagnostic and prognostic biomarkers for CAP.

INSTRUMENT(S): 6540 Q-TOF LC/MS (Agilent)

SUBMITTER: Yan Bingpeng

PROVIDER: MTBLS354 | MetaboLights | 2016-08-11

REPOSITORIES: MetaboLights

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Dataset's files

Source:

			Action	DRS
	MTBLS354	Other
	FILES	Other
	a_MTBLS354_cap_metabolite_profiling_mass_spectrometry-1.txt	Txt
	a_MTBLS354_cap_metabolite_profiling_mass_spectrometry.txt	Txt
	i_Investigation.txt	Txt

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Publications

Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia.

To Kelvin K W KK Lee Kim-Chung KC Wong Samson S Y SS Sze Kong-Hung KH Ke Yi-Hong YH Lui Yin-Ming YM Tang Bone S F BS Li Iris W S IW Lau Susanna K P SK Hung Ivan F N IF Law Chun-Yiu CY Lam Ching-Wan CW Yuen Kwok-Yung KY

Diagnostic microbiology and infectious disease 20160314 2

Early diagnosis of acute community-acquired pneumonia (CAP) is important in patient triage and treatment decisions. To identify biomarkers that distinguish patients with CAP from non-CAP controls, we conducted an untargeted global metabolome analysis for plasma samples from 142 patients with CAP (CAP cases) and 97 without CAP (non-CAP controls). Thirteen lipid metabolites could discriminate between CAP cases and non-CAP controls with area-under-the-receiver-operating-characteristic curve of >0.8 ...[more]

PMID: 27105773

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