Ontology highlight
ABSTRACT:
SUBMITTER: Wiriyasermkul P
PROVIDER: S-EPMC7175901 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Wiriyasermkul Pattama P Moriyama Satomi S Nagamori Shushi S
Biochimica et biophysica acta. Biomembranes 20200422 12
Melanosomes are unique organelles in melanocytes that produce melanin, the pigment for skin, hair, and eye color. Tyrosinase is the essential and rate-limiting enzyme for melanin production, that strictly requires neutral pH for activity. pH maintenance is a result of the combinational function of multiple ion transport proteins. Thus, ion homeostasis in melanosomes is crucial for melanin synthesis. Defect of the ion transport system causes various pigmentation phenotypes, from mild effect to se ...[more]