Thin silk fibroin films as a dried format for temperature stabilization of inactivated polio vaccine.

ABSTRACT: Current inactivated polio vaccine (IPV) products are sensitive to both freezing and elevated temperatures and therefore must be shipped and stored between 2 °C and 8 °C, a requirement that imposes financial and logistical challenges for global distribution. As such, there is a critical need for a robust, thermally stable IPV to support global polio eradication and post-eradication immunization needs. Here, we present the development of air-dried thin films for temperature stabilization of IPV using the biomaterial silk fibroin. Thin-film product compositions were optimized for physical properties as well as poliovirus D-antigen recovery and were tested under accelerated and real-time stability storage conditions. Silk fibroin IPV films maintained 70% D-antigen potency after storage for nea

SUBMITTER: Stinson JA 

PROVIDER: S-EPMC7176408 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature