Ontology highlight
ABSTRACT:
SUBMITTER: Liberman N
PROVIDER: S-EPMC7176415 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Science advances 20200422 17
During stress, global translation is reduced, but specific transcripts are actively translated. How stress-responsive mRNAs are selectively translated is unknown. We show that METL-5 methylates adenosine 1717 on 18<i>S</i> ribosomal RNA in <i>C. elegans</i>, enhancing selective ribosomal binding and translation of specific mRNAs. One of these mRNAs, CYP-29A3, oxidizes the omega-3 polyunsaturated fatty acid eicosapentaenoic acid to eicosanoids, key stress signaling molecules. While <i>metl-5-</i> ...[more]