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Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds.

ABSTRACT: The methanol extract of Cassia auriculata seeds was found to inhibit melanogenesis in B16 melanoma 4A5 cells under conditions of theophylline stimulation. Two new phlegmacin-type anthracenone dimer glycosides, auriculataosides A and B, were isolated from the active methanol fraction, and their inhibitory effects were observed in the concentration range of 0.03 to 0.3 ?M. Inhibition of microphthalmia-associated transcription factor, tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 protein expression was observed, suggesting that the inhibition of these factors is part of the mechanism of action underlying melanogenesis inhibition.

SUBMITTER: Wang W

PROVIDER: S-EPMC7176596 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Inhibition of melanin production by anthracenone dimer glycosides isolated from Cassia auriculata seeds.

Wang Weicheng W Zhang Yi Y Nakashima Souichi S Nakamura Seikou S Wang Tao T Yoshikawa Masayuki M Matsuda Hisashi H

Journal of natural medicines 20190307 3

The methanol extract of Cassia auriculata seeds was found to inhibit melanogenesis in B16 melanoma 4A5 cells under conditions of theophylline stimulation. Two new phlegmacin-type anthracenone dimer glycosides, auriculataosides A and B, were isolated from the active methanol fraction, and their inhibitory effects were observed in the concentration range of 0.03 to 0.3 μM. Inhibition of microphthalmia-associated transcription factor, tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2 protei ...[more]

PMID: 30847755

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