Ontology highlight
ABSTRACT:
SUBMITTER: Figueiredo ML
PROVIDER: S-EPMC7177159 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Figueiredo Marxa L ML Figueiredo Neto Manoel M Salameh Janelle Wes JW Decker Richard E RE Letteri Rachel R Chan-Seng Delphine D Emrick Todd T
Molecular therapy. Methods & clinical development 20200330
We have examined the role of a novel targeted cytokine, interleukin-27 (IL-27), modified at the C terminus with a dual targeting and therapeutic heptapeptide, in treating prostate cancer. IL-27 has shown promise in halting tumor growth and mediating tumor regression in several cancer models, including prostate cancer. We describe our findings on the effects of targeted IL-27 gene delivery on prostate cancer cells <i>in vitro</i> and <i>in vivo</i> and how the targeting enhances bioactivity of th ...[more]