Ontology highlight
ABSTRACT:
SUBMITTER: Soborg Pedersen K
PROVIDER: S-EPMC7179113 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Søborg Pedersen Kristina K Baun Christina C Michaelsen Nielsen Karin K Thisgaard Helge H Ingemann Jensen Andreas A Zhuravlev Fedor F
Molecules (Basel, Switzerland) 20200302 5
Despite promising anti-cancer properties in vitro, all titanium-based pharmaceuticals have failed in vivo. Likewise, no target-specific positron emission tomography (PET) tracer based on the radionuclide <sup>45</sup>Ti has been developed, notwithstanding its excellent PET imaging properties. In this contribution, we present liquid-liquid extraction (LLE) in flow-based recovery and the purification of <sup>45</sup>Ti, computer-aided design, and the synthesis of a salan-<sup>nat</sup>Ti/<sup>45</ ...[more]