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ARGONAUT II Study of the In Vitro Activity of Plazomicin against Carbapenemase-Producing Klebsiella pneumoniae.

ABSTRACT: Plazomicin was tested against 697 recently acquired carbapenem-resistant Klebsiella pneumoniae isolates from the Great Lakes region of the United States. Plazomicin MIC50 and MIC90 values were 0.25 and 1?mg/liter, respectively; 680 isolates (97.6%) were susceptible (MICs of ?2?mg/liter), 9 (1.3%) intermediate (MICs of 4?mg/liter), and 8 (1.1%) resistant (MICs of?>32?mg/liter). Resistance was associated with rmtF-, rmtB-, or armA-encoded 16S rRNA methyltransferases in all except 1 isolate.

SUBMITTER: Jacobs MR

PROVIDER: S-EPMC7179617 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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ARGONAUT II Study of the In Vitro Activity of Plazomicin against Carbapenemase-Producing Klebsiella pneumoniae.

Jacobs Michael R MR Good Caryn E CE Hujer Andrea M AM Abdelhamed Ayman M AM Rhoads Daniel D DD Hujer Kristine M KM Rudin Susan D SD Domitrovic T Nicholas TN Connolly Lynn E LE Krause Kevin M KM Patel Robin R Arias Cesar A CA Kreiswirth Barry N BN Rojas Laura J LJ D'Souza Roshan R White Richard C RC Brinkac Lauren M LM Nguyen Kevin K Singh Indresh I Fouts Derrick E DE van Duin David D Bonomo Robert A RA

Antimicrobial agents and chemotherapy 20200421 5

Plazomicin was tested against 697 recently acquired carbapenem-resistant Klebsiella pneumoniae isolates from the Great Lakes region of the United States. Plazomicin MIC50 and MIC90 values were 0.25 and 1 mg/liter, respectively; 680 isolates (97.6%) were susceptible (MICs of ≤2 mg/liter), 9 (1.3%) intermediate (MICs of 4 mg/liter), and 8 (1.1%) resistant (MICs of >32 mg/liter). Resistance was associated with rmtF-, rmtB-, or armA-encoded 16S rRNA ...[more]

PMID: 32152078

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