Ontology highlight
ABSTRACT:
SUBMITTER: Popitsch N
PROVIDER: S-EPMC7186786 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Genome biology and evolution 20200401 4
In animals, the most common type of RNA editing is the deamination of adenosines (A) into inosines (I). Because inosines basepair with cytosines (C), they are interpreted as guanosines (G) by the cellular machinery and genomically encoded G alleles at edited sites mimic the function of edited RNAs. The contribution of this hardwiring effect on genome evolution remains obscure. We looked for population genomics signatures of adaptive evolution associated with A-to-I RNA edited sites in humans and ...[more]